Venous blood samples were collected from all participants on the day they were invited to participate in this study to determine the levels of HbA1c, TSH, FT3, FTcuatro, and antithyroid antibodies and the lipid profile. The hemoglobin A1c (HbA1c) level was measured using the National Glycohemoglobin Standardization Program (NGSP)-standardized and Diabetes Control and Complications Trial (DCCT)-compliant immune turbidimetric assay (Hoffman-La Roche Ltd., Basel, Switzerland), with an inter-measurement coefficient of variation of 1.64% according to the manufacturer’s specifications. The reference range was 4.8–6.4% . Lipid profile was assessed using spectrophotometry (enzymatic-colorimetric), and the following reference values were set: total cholesterol 50 mg/dL.
Antithyroid peroxidase (anti-TPO) and antithyroglobulin (anti-Tg) antibodies were detected in venous blood samples using the electrochemiluminescence immunoassay (ECLIA). The upper normal limit for the anti-TPO antibody was set at 34 UI/mL and for the anti-Tg antibody at 115 U/mL . Values greater than these cut-off values indicated positive results. For the evaluation of thyroid function, TSH, FT4, and FT3 levels were measured using ECLIA. The following reference values were used: TSH = 0.465–4.68 Miu/mL, FT3 = 3.69–10.4 pmol/L, and FT4 = 10–28.2 pmol/L . Thyroid ultrasonography was performed in all cases to measure the thyroid volume and study the changes in parenchymal density. The presence of an enlarged thyroid (thyroid gland volume > 97th age-related percentile) with diffuse hypo-echogenicity and/or diffuse micronodules confirmed the diagnosis of autoimmune thyroiditis.
This new diagnosis of retinopathy was centered immediately after funduscopic examination used because of the a trained ophthalmologist exactly who aimed at diabetic attention complications. Podiatric examination are did according to the standardized protocol and integrated inspections off vibration and you may tactile, soreness, and you can thermic feelings; photoplethysmography; and you may measurement off foot and you will bottom blood pressure levels to search for the ankle/brachial and you will toe/brachial indexes, respectively. Ewing’s power take to try performed to ensure the fresh new medical diagnosis regarding cardiac autonomic neuropathy. In many cases, echocardiography and Doppler ultrasound of carotid artery were utilized in order to determine the seriousness of macrovascular complications.
Comparison away from erectile dysfunction
The first FSDS size was designed to level distress, that’s probably one of the most very important the signs of FSD . I used the revised adaptation (FSDS-R), comprising 13 questions, where in fact the standard of distress was counted since the a frequency. Brand new effect scale per question’s product selections ranging from 0 (never) and you may 4 (always). Stuff are summed up to acquire a complete score ranging from 0 to help you 52. The fresh slash-of rating was ? eleven .
The newest European variety of the FSFI is translated, examined, and you will authorized by the Lookup Panel of one’s Timisoara State Crisis Medical for use on the Romanian inhabitants. The newest FSFI includes 19 issues into the six attributes of new girls intimate response: notice, arousal, oiling, orgasm, pleasure, and you may soreness. The fresh new answers are analyzed considering how often for each and every function occurs. To your FSFI, minimal get is 2 plus the limit try 36, into the slash-regarding get from 26.5 . The size includes inquiries on the six domains, specifically desire, personal pleasure, lubrication, climax, pleasure, and you can soreness. The person website name score are listed below: step 1.2–6 getting manhunt login focus; 0–6 getting pleasure, lubrication, orgasm, and aches; and you may 0.8–six for pleasure. Low results mean higher symptom weight . This new patients were questioned to accomplish these types of questionnaires in the home and you will go back him or her just after 4 weeks. Patients just who didn’t return new questionnaire timely had been delivered an indication thru mobile.
Testing of depression
To have examining the degree of depression, i utilized the BDI-II measure , spanning 21 issues, that have at least score of 0 and you may a maximum of 63, and you may a cut right out-from rating out-of ? 17 . The fresh customers was basically requested to do that it survey at home and you may send it back just after a month. Patients whom did not get back the fresh new survey on time had been delivered an indication through mobile phone.